Dave Lizewski is an unnoticed high school student and comic book fan who one day decides to become a super-hero, even though he has no powers, training or meaningful reason to do so.

A loser of a crook and his wife strike it rich when a botched bank job's cover business becomes a spectacular success.

Ray Barone is a successful sportswriter living on Long Island with his wife Debra, daughter Ally, and twin sons, Geoffrey and Michael. That's the good news. The bad news? Ray's meddling parents, Frank and Marie, live directly across the street and embrace the motto "Su casa es mi casa," infiltrating their son's home to an extent unparalleled in television history.