4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.

A pair of buddies conspire to save their best friend from marrying the wrong woman, a cold-hearted beauty who snatches him from them and breaks up their Neil Diamond cover band.

A police chief about to retire pledges to help a woman find her daughter's killer.

Lance Henriksen is a successful restauranteur who is having a hot n' heavy affair with the wife (Susan Tyrell) of a Presidential Adviser. During one rendezvous they overhear the husband and an Admiral discussing "the killing of the patient", and as the adulterous couple have been under surveillance this information reaches a top Federal Agent (Patrick O'Neal) who provides security for the President. His investigation begins to cast light on a conspiracy within government to assassinate the President - and now he must expose the conspiracy and stop it cold.