A year ago, vampires, werewolves and zombies mysteriously descended upon the streets of California's San Fernando Valley. The Undead Task Force (UTF) was created to combat the emergence of monsters.

Three wealthy children's parents are killed in a fire. When they are sent to a distant relative, they find out that he is plotting to kill them and seize their fortune.

A college freshman goes to a frat party and wakes up with a strange thirst for blood. He soon discovers the fraternity is actually secret society of vampires and that he is their newest recruit.

Will Truman and Grace Adler are best friends living in New York, and when Grace's engagement falls apart, she moves in with Will. Together, along with their friends, they go through the trials of dating, sex, relationships and their careers, butting heads at times but ultimately supporting one another while exchanging plenty of witty banter along the way.