An angry wife seeks revenge against her philandering entrepreneur husband who left her for a younger woman.

A big-city female doctor returns to her roots in the backwoods of the Blue Ridge Mountains to bring modern medicine to the local folks in the Appalachia of the 1930s and finds herself at odds with the homespun ways of the resident medicine woman.

The young Harold lives in his own world of suicide-attempts and funeral visits to avoid the misery of his current family and home environment. Harold meets an 80-year-old woman named Maude who also lives in her own world yet one in which she is having the time of her life. When the two opposites meet they realize that their differences don’t matter and they become best friends and love each other.