The cast of an old TV show called reunites for their 20th anniversary; during the event, a quadruple homicide turns everyone into a suspect.

When an in-flight collision incapacitates the pilots of an airplane bound for Los Angeles, stewardess Nancy Pryor is forced to take over the controls. From the ground, her boyfriend Alan Murdock, a retired test pilot, tries to talk her through piloting and landing the 747 aircraft. Worse yet, the anxious passengers — among which are a noisy nun and a cranky man — are aggravating the already tense atmosphere.