Salvo and Valentino are two Sicilian friends who have moved to Turin, and now run a small business together. They drive foreign tourists around in a double-decker bus, and Salvo always tries to approach the pretty girls.

Zurich, 1905. Nineteen-year-old Russian Sabina Spielrein is put by her parents in a psychiatric hospital, suffering from a severe form of hysteria and refusing to eat. A compassionate doctor, Carl Gustav Jung, takes her under his care and, for the first time, experiments with the psychoanalytical method of his teacher Sigmund Freud. Thus is born a sweeping story of love and passion, of body and soul, soaring to the utmost heights, but also plunging to the darkest depths of the 20th century.