Fifty years after a world-wide zombie epidemic had begun, a small group of rebel soldiers learn that intelligent zombies have begun breeding humans for food. The soldiers plan an all-out war to rid the Earth of the flesh-eating monsters for good, as the rest of the surviving world's population struggles to survive against the zombie hordes.

While the original parodied slasher flicks like Scream, Keenen Ivory Wayans's sequel to Scary Movie takes comedic aim at haunted house movies. A group of students visit a mansion called "Hell House," and murderous high jinks ensue.