In the early 70s, Cathy Rush becomes the head basketball coach at a tiny, all-girls Catholic college. Though her team has no gym and no uniforms -- and the school itself is in danger of being sold -- Coach Rush looks to steer her girls to their first national championship.

A deadly infection breaks out in Manhattan, causing humans to devolve into blood-thirsty rat creatures. Six recently evicted tenants must survive the night and protect their downtown apartment building as the city quickly spirals out of control.