A deadly infection breaks out in Manhattan, causing humans to devolve into blood-thirsty rat creatures. Six recently evicted tenants must survive the night and protect their downtown apartment building as the city quickly spirals out of control.

Seven strangers assemble at a lavish dinner party given by an unseen host. Soon, the guests are all driven to lust, murder and madness.

A mysterious drifter causes even more problems for an already dysfunctional family.