The teenagers of Disney's most infamous villains return to the Isle of the Lost to recruit a new batch of villainous offspring to join them at Auradon Prep.

Martial arts champion Andre Lima's fighting days ended with his wife's death. The past nine years Andre has struggled to rebuild his world around his two children. When his daughter's health suddenly fails, his finances collapse.

Mick St. John is a captivating, charming and immortal private investigator from Los Angeles, who defies the traditional blood-sucking norms of his vampire tendencies by using his wit and powerful supernatural abilities to help the living.

In a futuristic world, Michelle lives everyday battling with DNA Hackers who use their skills to hack into people's bodies and kill them. She is an assassin, trying to keep her younger brother, Jackie, out of trouble. When Jackie gets involved in a petty crime of robbery, he propels himself into the world of DNA Hackers, Shylocks (Loan Sharks) and Gangs

Texan Charles Farmer left the Air Force as a young man to save the family ranch when his dad died. Like most American ranchers, he owes his bank. Unlike most, he's an astrophysicist with a rocket in his barn - one he's built and wants to take into space. It's his dream. The FBI puts him under surveillance when he tries to buy rocket fuel, and the FAA stalls him when he files a flight plan – but Charles is undeterred.