The detectives of the Organized Crime Control Bureau work to dismantle New York City's most vicious and violent illegal enterprises.

In Brooklyn live two young street musicians who since childhood dream of building a recording studio together. Charlie, who plays the banjo, just inherited a house with a large basement. His best friend and manager Ted thinks it might be the perfect place for the studio but they need $ 25,000 to fulfill their dream. One day a Jamaican nurse approaches them on the street asking for help to lift a patient who has fallen down. Ted finds a collection of rare baseball cards in the house of the patient, and soon will plot a plan to steal the valuable collection to finance their studio. But when Charlie gets involved in a relationship with the nurse, Ted plans will be disrupted and his friendship with Charlie threatened.

After her husband leaves her for a younger woman, Alice Washington a middle aged mother of two decides to complete her college education at Smith College. She and her 20 year old room mate Zoe Burns share their experiences, conflicts and interest in their poetry professor.

The series follows the ventures of a Missing Persons Unit of the FBI in New York City.