Mitch Buchannon (David Hasselhoff) was believed to have died in a boating accident at the end of the 10th season of Baywatch. However, it turns out he only had amnesia and has been recovering in a Los Angeles hospital. His new fiancée, Allison Ford (Alexandra Paul), resembles his old lover, Lt. Stephanie Holden (also played by Alexandra Paul), who died during the seventh season of Baywatch. However, she is cooperating with an old nemesis of Mitch's, the still undead Mason Sato (Cary-Hiroyuki Tagawa) from the second season, to get revenge on Mitch.

The vampire Angel, cursed with a soul, moves to Los Angeles and aids people with supernatural-related problems while questing for his own redemption. A spin-off from Buffy the Vampire Slayer.

Using footage left over from Nemesis 2 and a very thin story line sees Alex again fighting the cyborg mercenaries in 1998 East Africa. This time, Alex finds that she has 20 half sisters who are waiting for her to return to 2077. Central Command wants Alex captured alive and scanned to see if her DNA is a strong and more powerful strain than the normal. But Alex may be too tough for Farnsworth to capture.

It has been 73 years since Alex failed and the Humans lost the Cyborg Wars. Since then, the Humans have been enslaved. Scientists have developed a new DNA strain, which could signal the end of the Cyborgs, and they inject it into a volunteer. When the Cyborgs learn of the woman and the baby they list both for termination.

"First Strike" pilots have the mission of destroying nuclear arms that have fallen into the hands of bandits.