Syd March is an employee at a clinic that sells injections of live viruses harvested from sick celebrities to obsessed fans. When he becomes infected with the disease that kills super sensation Hannah Geist, Syd becomes a target for collectors and rabid fans. He must unravel the mystery surrounding her death before he suffers the same fate.

In the wake of the end of the world, a family of four desperately tries to survive. Their goal: escaping the city and traveling to the rural community they once called home. The constant threat of a violent death forcing them to stay as far away from civilization as possible, they take to the forest, soon to discover the danger posed by other survivors may be the least of their worries.

Major real-life air disasters are depicted in this series. Each episode features a detailed dramatized reconstruction of the incident based on cockpit voice recorders and air traffic control transcripts, as well as eyewitnesses recounts and interviews with aviation experts.