A trio of hunters in the Louisiana bayous capture a monster called the Swamp Thing. They take it to New Orleans where (naturally) they display it in a strip joint. When the monster's favorite stripper gets into a fight with another stripper, he breaks loose and starts killing.

Following a live orchestra opening, emcee Eddie Garr greets the audience and tells them about his trip to Los Angeles, where out-of-work actors are always 'acting' while in their service-industry jobs. What follows is a cavalcade of wild and wacky performances.

The Ed Sullivan Show is an American TV variety show that originally ran on CBS from Sunday June 20, 1948 to Sunday June 6, 1971, and was hosted by New York entertainment columnist Ed Sullivan. It was replaced in September 1971 by the CBS Sunday Night Movie, which ran only one season and was eventually replaced by other shows. In 2002, The Ed Sullivan Show was ranked #15 on TV Guide's 50 Greatest TV Shows of All Time.

Dozens of star and character-actor cameos and a message about the Variety Club (a show-business charity) are woven into a framework about two hopeful young ladies who come to Hollywood, exchange identities, and cause comic confusion (with slapstick interludes) throughout the Paramount studio.