Feed Me is a story about a young family in a suburban area in Southern California. The father, Jason (Cameron Graham), is an ambitious executive who keeps getting promoted in a large corporation. The mother, Christy (Mitra Avani), is a step aerobics instructor, who dedicates her life to caring for her 4 years old daughter Alicia (Duna DiVito). However, everything changes when Alicia suddenly starts disappearing every night. Jason contemplates his job security in devoting a great deal of time to this disturbing family issue. Christy believes that she can save her daughter by developing her medium skills. Alicia seems to remember nothing when she reappears, and malevolent forces may be placing her in a state between the unconscious to the subconscious.

Lidia is a responsible and dedicated maid for a hugely wealthy, elderly Tijuana matron who loves only her pet whippet. Rafael is a quiet and dignified janitor who buys a new pair of shoes to celebrate his imminent retirement from the large corporate facility where he's worked for 30 years. When Lidia's boss dies, leaving everything to her dog, and Rafael's plans get derailed, they both turn to criminal subterfuge to get what their harsh lot in life has denied them.

When she was 11, young Faron Hallowell was sent away to a mental institution for shooting and nearly killing a local weatherman--a secret mission she claimed was assigned to her by alien beings. Now, five years later, released and rehabilitated, all she wants is a normal life. But when the events of her dark past return to haunt her, she'll have to use her uncanny abilities once again to protect.

Street sweeper Joe Fallow is approached by the ailing Grim Reaper who offers to train him as his replacement and become the new 'face of death'. Elsewhere in town, an evil force threatens to merge the worlds of Hell and Earth into one. And only Joe, assisted by an enigmatic supernatural bounter-hunter, can stop it from happening.