H6 tells the story of Antonio Frau, a serial killer set free after serving 25 years in jail for the violent murder of his girlfriend. After inheriting and old motel from a relative he never knew, he sees this as a signal and takes to his holy task of relieving the grief of those who have lost the will to live. He takes his victims to room Number 6 in the motel where he 'purifies' them, while, at the same time, continues his everyday life next to his wife. A mistake leads to his arrest, and his plan to become rich and famous takes relevance.

Crista, Berta and Sole, are three young people who feel exploited and discriminated by society.

Obsessed with fantasies of sex, Father Miguel seeks professional help through his church but they are not listening; thus leaving the Father in a dilemma; leaving the church or should he try, on his own, to surrender to these temptations?