Doreen is about to marry the man of her dreams, Hank, a mild-mannered guy who is equally as excited about marrying Doreen. However, Doreen's older brother, a wild man named Travis who's been estranged from her for several years, shows up to make amends, but instead he accidentally curses her. Doreen is now possessed by the devil. In Las Vegas is a homeless man known as Johnny Priest, who is the last known person to perform an exorcism in America. It's up to Travis and Hank to put aside their differences and travel from Chicago to Las Vegas to get Doreen an exorcism before it's too late and her soul is lost forever.

Thirty-something geek Tom Stewart has always loved cheap old horror and monster movies. He's decided to pursue a dream to create a horror host TV show in an age when infomercials are more important to local television stations than original programming. When TV60-WPM gives Tom his chance, his struggle begins, leading to unexpected and unwanted compromises in all aspects of his life. Before long, Tom wonders if the show's slowly growing success is worth the pain it takes to get there...but he doesn't have to shoulder the burdens alone. "Thriller Theater!" is a gently comedic feel-good movie about the struggle to find a balance between "real life" and the pursuit of one's creative dreams.