Amandla is an anti-apartheid resistance slogan and means power. Apartheid in South Africa is still in full force when, in 1987, the two brothers Impi and Nkosana grew up on a farm as the sons of servants. The white owners are liberal people who aren't too particular about racial segregation. Black Africans have it relatively good there. Even a tender love bond develops between Impi and the blond daughter Elizabeth. But they have to be on their guard when neighboring farmers come to visit. When three racist upstart Boers arrive on the farm one day, tragic incidents occur with terrible consequences. The two Zulu boys are now on their own. Several years after surviving this childhood tragedy, the now grown brothers each find themselves on the opposing sides of the law. One is a gangster, the other is a police officer. A heinous gang crime tests their loyalty to one another.

The plot follows the individual journeys of three ordinary South African men in the build up to their attendance of the 2010 Mighty Men Conference, where their lives are forever changed by God's message for them.