For their first day on the job as the new protectors of Metro City, Megamind and Minion are selling off the gadgets from their evil lair. But when one seemingly harmless "button" unleashes the gigantic robot MEGA-MEGAmind, the duo will have to resort to their old tricks to restore order.

Alex, Marty, and other zoo animals find a way to escape from Madagascar when the penguins reassemble a wrecked airplane. The precariously repaired craft stays airborne just long enough to make it to the African continent. There the New Yorkers encounter members of their own species for the first time. Africa proves to be a wild place, but Alex and company wonder if it is better than their Central Park home.