A newly married couple, in the process of starting a family, learn many of life's important lessons from their trouble-loving retriever, Marley. Packed with plenty of laughs to lighten the load, the film explores the highs and lows of marriage, maturity and confronting one's own mortality, as seen through the lens of family life with a dog.

When a deadly airborne virus threatens to wipe out the northeastern United States, teacher Elliott Moore and his wife Alma flee from contaminated cities into the countryside in a fight to discover the truth. Is it terrorism, the accidental release of some toxic military bio weapon -- or something even more sinister?