Dr. Beaumont Rosewood, Jr. is a brilliant private pathologist who uses wildly sophisticated technology and his drive to live life to the fullest to help a tough-as-nails detective and the Miami PD uncover clues no one else can see.

There is an old wives tale that you should hold your breath when passing by a cemetery because an evil spirit rejected by both heaven and hell can get inside of you when you inhale. Somewhere in a carload of college kids on holiday doesn't follow the rules when driving by a graveyard, allowing a spirit of a recently executed serial killer to get inside him/her to begin a killing spree of body-jumping carnage.

A homeless alcoholic living on Skid Row dons himself a Private Investigator to solve cases for others living on the street.