Obstetrician/gynecologist Mindy Lahiri tries to balance her personal and professional life, surrounded by quirky co-workers in a small medical practice in New York City.

In the not too distant future a secret government re-animation chemo-virus gets released into conservative Sartre, Nebraska and lands in an underground strip club. As the virus begins to spread, turning the strippers into "Super Zombie Strippers" the girls struggle with whether or not to conform to the new "fad" even if it means there's no turning back.

A turn of the century ritual to raise the feminine evil goes horribly awry and leaves a she demon dormant on the ceremonial grounds. Sixty years later a young couple moves into a house built on the ancient grounds and their daughter's murder leaves the house abandoned for yet another forty years. Now, six fun loving college students are hired to clean up the house for a greedy real estate mogul who plans to sell it for a large profit. They unwittingly awake the demon and only the ultimate sacrifice can save the world from a future of unspeakable evil.