Still in the thrall of the evil vampire Radu, Michelle yearns to be taught the skills of the vampire. Meanwhile, her sister Becky tries to free her from his evil clutches, and this time, she's brought some help.

In his hidden laboratory deep in Russia, Dr. Karl Zimmer has invented the Mandroid, a humanoid robot which follows the motions of a man in a special control suit. He has offered the invention to the USA, who have sent Smith and Wait from the CIA for inspection. However Zimmer's partner Drago has different plans, wants to sell Mandroid to the military. The night he tries to steal Mandroid, he becomes exposed to the highly toxic Superconn. But he can flee and won't give up on Mandroid, even though he's terribly disfigured.

Continuing after the first "Subspecies", a woman who has just become a vampire tries to escape the evil vampire, Radu, who seeks her as his love interest. But she has taken the vampire family's bloodstone, and now Radu must find her to get it back. While her sister comes to Romania to save her soul. It might be too late....