At the beginning of the 20th century, a newspaper organizes an endurance horse race : 700 miles to run in a few days. 9 adventurers are competing, among them a woman, Miss Jones, a Mexican, an Englishman, a young cow-boy, an old one and two friends, Sam Clayton and Luke Matthews. All those individualists will learn to respect each other.

Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.

A man with a dog helps a young woman being chased by hoodlums in the desert.

An arrogant Texas millionaire hires four adventurers to rescue his kidnapped wife from a notorious Mexican bandit.