A fanatical animal rights activist releases giant pythons into the Everglades, believing the wild animals should be set free. When they start decimating the native animal population, an over-zealous park ranger feeds experimental steroids to wild alligators so they can fight back. The giant pythons and gargantuan alligators go on a killing spree, and it is now left up to the two feuding women to put aside their differences to put a stop to the creatures and the destruction.

A San Francisco spoken word artist returns to New Mexico to be with his dying father, only to find he loses his "voice" as he is sucked back in to the dysfunctional life of drugs and violence he left behind.