Describing herself as a 'street queen,' Johnson was a legendary fixture in New York City’s gay ghetto and a tireless voice for LGBT pride since the days of Stonewall, who along with fellow trans icon Sylvia Rivera, founded Street Transvestites Action Revolutionaries (S.T.A.R.), a trans activist group based in the heart of NYC’s Greenwich Village. Her death in 1992 was declared a suicide by the NYPD, but friends never accepted that version of events. Structured as a whodunit, with activist Victoria Cruz cast as detective and audience surrogate, The Death and Life of Marsha P. Johnson celebrates the lasting political legacy of Johnson, while seeking to finally solve the mystery of her unexplained death.

From the onset of the AIDS epidemic, author Larry Kramer emerged as a fiery activist, an Old Testament-style prophet full of righteous fury who denounced both the willful inaction of the government and the refusal of the gay community to curb potentially risky behaviors. Co-founder of both organization Gay Men's Health Crisis and the direct action protest group ACT UP, Kramer was vilified by some who saw his criticism to be an expression of self-hatred, while lionized by others who credit him with waking up the gay community — and, eventually, the government and medical establishment — to the devastation of the disease.

In the aftermath of Stonewall, a newly politicized Vito Russo found his voice as a gay activist and critic of LGBTQ+ representation in the media. He went on to write "The Celluloid Closet", the first book to critique Hollywood's portrayals of gays on screen. During the AIDS crisis in the 1980s, Vito became a passionate advocate for justice via the newly formed ACT UP, before his death in 1990.

On January 22, 1993 at the historic Castro Theater in San Francisco, Lily Tomlin, Robin Williams, Harvey Fierstein, Marga Gomez, and Lypsinka performed a one-night only benefit for the making of the film The Celluloid Closet, both directed by Rob Epstein and Jeffrey Friedman.

In New York City, a distraught activist confronts the mayor with a story of a friend who languished on a cot in an emergency room hallway for nine days, only to die 48 hours after leaving the hospital. In 1988, thousands of activists hold the Food and Drug Administration under siege, demanding speedier drug approval. In 1990 AIDS activists converge on the National Institute of Health, calling for a more equitable clinical trial system and expanded research into new drugs and treatment. Voices From the Front, the first feature-length documentary on AIDS activism in America, makes clear the emotional and political effects of community activism using the voices of those directly engaged. It is a powerful distillation of pictures and words from events organized to change public consciousness, expose the failure of the health care systems, and challenge government inaction and neglect concerning AIDS.

On the eve of 1987's Second National March on Washington for Lesbian and Gay Rights, surviving families and friends of people who have died of AIDS prepare panels to be added to a large-scale memorial quilt project. Drawing from the sea of names memorialized, director Robert Epstein focuses on the lives of six people. Alongside the intimate profiles offered, through news footage and interviews, Epstein puts the AIDS crisis in the larger context of social and government response to the disease.

When David, an ex-monk still in his twenties meets Mark, he falls hard; soon he's asked Mark if they can live together. Things go well for awhile, and then differences in their definition of "commitment" begin to push them apart. Mark wants other sexual adventures, David tries to go along. Can they talk through the crisis in their relationship or is a breakup in the offing? David sees his relationship with Mark as a marriage, so if it ends, can David's heart ever heal?