Set in Harlem in 1987, Claireece "Precious" Jones is a 16-year-old African American girl born into a life no one would want. She's pregnant for the second time by her absent father; at home, she must wait hand and foot on her mother, an angry woman who abuses her emotionally and physically. School is chaotic and Precious has reached the ninth grade with good marks and a secret; She can't read.

After twelve years in prison, Walter returns home. His family has abandoned him, save for his brother-in-law. Few know he's a sex offender and pedophile. Walter finds an apartment and is regularly visited by his parole officer. He gets a job at a lumber mill and starts seeing a coworker. Then his new world begins to unravel; as his past becomes known, he strikes up a high-risk friendship with a young girl and realizes that a man loitering near a schoolyard is a child molester prowling for his next victim.