In and around some great blues, swing and jazz music, a very unpopular band-leader. Prince Ellis, is killed in a Harlem nightclub, and, in and around some more great music, a detective finds the lists of suspects is very long, as Prince Ellis was indeed very unpopular with many citizens.

Tommy McCoy and "Dude" Markey are both in love with Harlem singer/dancer Nita. Markey robs a jewelry store and turns the loot over to gang-boss Murray Howard. Later, Markey robs the safe, steals the jewelry, and, in order to get rid of his rival for Nita, frames the robbery on McCoy. The latter's big-brother thinks otherwise and, with Nita's help, sets out to prove it.

A wandering cowboy and his sidekick try to resolve a murder.

Bob Blake and his sidekick and four singing cowboys arrive at the Jackson ranch where Bob learns from Betty Jackson that her brother, Joe, is missing. Bob investigates and learns that there is gold on the Jackson ranch, and the neighboring rancher has kidnapped Joe in order to get his land.

A cowboy is wrongfully accused of murder. He winds up in Harlem, where he assumes the identity of a preacher-turned-gangster who looks like him. He infiltrates the gang to catch the men who framed him.

The story of the rise of boxer Joe Thomas, which paralleled the life of Joe Louis.