A career criminal nabbed by Mexican authorities is placed in a tough prison where he learns to survive with the help of a 9-year-old boy.

A married, middle-aged well-known biochemist and university teacher Augusto, leaves his wife, his job and the comfort of his life to go after Marlene, a 14-year-old teenager with extraordinary beauty who burst into his life unexpectedly. One day, Marlene is taken from the custody of Augustus by Genaro, a psychotic sailor, who seduces and finally kidnaps her by taking to the ominous port of Tampico, where Augustus will seek her to try to free her, not without giving her life to pain and atonement, undergoing a deep personal transformation.

Nacho Libre is loosely based on the story of Fray Tormenta ("Friar Storm"), aka Rev. Sergio Gutierrez Benitez, a real-life Mexican Catholic priest who had a 23-year career as a masked luchador. He competed in order to support the orphanage he directed.

"Taking Care of Business" - Conflicts between local gangsters arise.

Jose and Diana fall in love while living a world of drug trafficking.