An emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room.

Three strangers are selected, at random, to suffer a horrible death. Jeff, Robert, and Angie are thrown together in a dungeon and forced to wait their turn to die. No one can help because they are now the disappeared.

As an epidemic of a lethal airborne virus - that kills within days - rapidly grows, the worldwide medical community races to find a cure and control the panic that spreads faster than the virus itself.

Another woman has gone missing on the hottest day of the year. The death toll rises with the temperature, and while everyone else is staying in, Albert Mullin is out, prowling the streets and alleyways.