Shifty, a young crack cocaine dealer in London, sees his life quickly spiral out of control when his best friend returns home. Stalked by a customer desperate to score at all costs, and with his family about to turn their back on him for good, Shifty must out-run and out-smart a rival drug dealer, intent on setting him up for a big fall.

The film is set in Tuscany during the Black Death. As in the Decameron, ten young Florentines take refuge from the plague. But instead of telling stories, they have lusty adventures, bawdy exchanges, romance and swordplay. There are randy nuns, Saracen pirates, and a sexy cow.