A small West Virginia town is hosting the legendary Mountain Man Festival on Halloween, where throngs of costumed party goers gather for a wild night of music and mischief. But an inbred family of hillbilly cannibals kill the fun when they trick and treat themselves to a group of visiting college students.

A man crossing into Mexico with a satchel of $2,000,000—and a bloody past—finds himself under sudden attack in the sleepy town of El Fronteras.

Duff Daniels (John T. Woods), the younger, stupider brother of Les (Michael Shanks), can't help himself from stealing a rare snake that's been kept in a jar by a Native American snake dealer (Ben Cardinal), and which has to follow some rules: don't let it out of the jar, then don't let it eat anything anything living, and never fear the heart of the snake.

When he began fusing human and shark DNA, his colleagues laughed at him. Now his creation is taking his revenge, and they aren't laughing anymore.

The deranged military and former CIA agent Dean Cage is in a rehab program, trying to forget the traumatic loss of his best friend Scott in Bosnia. When he dates with his girl-friend and Scott's sister, Detective Amy Knight, in a dinning restaurant, he is mistakenly taken as being the CIA agent that is investigating the robbery of the military experiment EX by a man called Sullivan. He is injected with the drug and abducted by the thieves. Amy has six hours to find the also stolen antidote and save Dean's life.