Based on the novel Winterkill, by William Judson, Cold River is the story of an Adirondack guide who takes his young daughter and step-son on a long camping trip in the fall of 1932. When winter strikes unexpectedly early (a natural phenomenon known as a 'winterkill' - so named because the animals are totally unprepared for a sudden, early winter, and many freeze or starve to death), a disastrous turn of events leaves the two children to find their own way home without food, or protection from the elements.

An advertising man, emotionally estranged from his wife and those around him, has seduced and then fired and discarded his secretary. She pursues him and forces him to confront the squalor of his life.