A grim, merciless gunfighter known as Santana protects a young woman from the murderers of her family members and at the same time pursues a revenge against a traitor responsible for the death of his fellow soldiers years before.

The small desert town of Black City is held in a reign of terror by a nasty gang of criminals lead by the ruthless Bud Willer. Earnest, but inexperienced Sheriff Jack Ronson arrives in town to establish law and order. Mysterious bounty hunter Django helps Ronson out.

Seven masked bandits, whose chief calls himself "Mormon", kidnap young Susy, cousin of the mayor of Clayton City, Frank Clonny. Frank accepts the $15,000 ransom requested by the bandits and thinks of a plan which will permit him, with the help of Benson, the sheriff, to free his cousin, recover the money and capture the outlaws. The plan, though, is destined to fail, because one of the mayor's men, Donovan, allows the bandits to escape the trap. Benson then decides to call in Sartana, who the Mormon immediately tries to eliminate with the help of four killers: Buffalo, who kills with a bullwhip; Martinez, an expert knife thrower; Sullivan, a giant of incredible strength and Silky, a sly and fast gunslinger.

A young man comes to town to find the killer of his older brother. Aided by his two sidekicks and a bag containing $20,000 as bait, he hopes to draw out the gang and their leader, the suspected killer.