Donna and Taryn are federal drug enforcement agents based in the Hawaiian isles. Upon the success of a drug bust, they receive a call from Shane Aviation to fly an emergency package of vaccine from Molokai to Knox Island. Unbeknownst to them, Philippine representative Martinez has convinced Captain Andreas to use a reconnaissance satellite to locate a sunken ship laden with gold that the Japanese had pilfered during World War II. Meanwhile, a storm forces Donna and Taryn to land their plane on a remote island which harbors the gold. The hijinks ensue when they are joined by a host of nefarious types who have learned of the gold’s location.

Double agent Picasso Trigger is assassinated in Paris by double-crossing bad guy Miguel Ortiz. Then Ortiz begins eliminating agents of The Agency who were involved in his brother's death. The Agency (belatedly) springs into action to stop Ortiz' heinous activities. The usual gunplay, romance, and nifty toys with bombs ensue.

A Molokai-based civilian pilot and an undercover DEA agent intercept a delivery of diamonds intended for druglord Seth Romero. Seth, his henchmen, and other island undesirables launch a full-scale assault on the duo. If they're going to survive, they'll need the help of agent Rowdy Abilene and his partner/kickboxing expert Jade.