An office clerk loves entering contests in the hopes of someday winning a fortune and marrying the girl he loves. His latest attempt is the Maxford House Coffee Slogan Contest. As a joke, some of his co-workers put together a fake telegram which says that he won the $25,000 grand prize.

A reporter is frustrated with women after a string of failed relationships. But then he finds himself taking up the cause of a young women he believes is falsely accused of killing her husband.

Solomon Ginsberg is the President of International Pictures Corporation and hires Joan McAllister, an unemployed stenographer, to double for his star, Laura Girard. While on a location trip, Laura is killed in an automobile accident, and in order to save the money already invested in the film Ginsberg, aided by the film's leading-man, Wallace Morely, with whom Joan is more than a little infatuated, persuades Joan to assume the identity of the dead actress, whose death is being concealed.

A "mama's boy" falls for a spinster who takes care of children at a department store nursery.

A mother abandons her family only to become a crispy critter with her lover, the husband finds out about it AND that his son isn't really his, becomes an alcoholic, is being held prisoner in a speak-easy, is rescued by 'Beef', is sobered up, gets a good job, negotiates a great contract for lots 'o money, realizes he's in love, asks the girl to marry him, son returns from boarding school and freaks out when told this, runs off and joins the circus that now happens to catch fire.....

When a movie actor is shot and killed during production, the true feelings about the actor begin to surface. As the studio heads worry about negative publicity, one of the writers tags along as the killing is investigated and clues begin to surface.

Jack Oakie plays Eddie Doyle, a gumball machine salesman who marries Pat Smith (Shirley Grey) knowing full well that the girl is on the rebound from a failed romance with aspiring Jewish doctor Max Silver (Leon Ames). But when Pat is nearly killed in an effort to protect her husband's gumball machines from hoodlums and is in need of a lifesaving operation, Eddie calls on Dr. Max

An out-of-work pants presser starts an umbrella business and makes a fortune. His daughter is set to marry the nephew of a rich neighbor until the nephew is accused of stealing money from his uncle--but the money was really stolen by the rich man's son.

A motion picture producer has press agent Jimmy Austin take Mary Callahan, a pretty shopgirl, to Europe. After an extensive publicity campaign, Mary returns to the United States as Maritza Callahansky, a Russian actress owning the crown jewels. To add support to her newly established identity, Maritza gives a party in a Long Island mansion in the rightful owner's absence. The owners return to find their home taken over by strangers and are about to call the police when it is discovered that they are the parents of one of the extras in the company.

Goldwyn produced a 1923 film adaptation of Potash and Perlmutter, and a 1924 sequel called In Hollywood with Potash and Perlmutter. In Partners Again the two are in the automobile industry -- This is a lost Film.

A sequel of sorts, the Jewish ethnic comedy characters of Potash and Perlmutter return from their 1923 debut film, also produced by Goldwyn, but with a different actor for Potash.

The film is based on an ethnic Jewish comedy with characters created by Montague Glass and Charles Klein.