First Wave is a Canadian/American science fiction television series, filmed in Vancouver, British Columbia, Canada, that aired from 1998 to 2001 on the Sci-Fi Channel. The show was created by Chris Brancato, who co-wrote an early version of the script for the seminal X-Files episode "Eve". Francis Ford Coppola was executive producer on the show. In an unusual move, the Sci-Fi Channel picked up the series on a 66-episode contract. The show was subsequently canceled once the contract expired at the end of the third season due to disappointing ratings.

Ryan Harrison, a violin god, superstar and sex symbol does not want to cheat on sexy Lauren Goodhue's husband with her. Mr. Goodhue is found murdered and Ryan suddenly finds himself being the main suspect. After being sentenced to death he manages to flee while being transferred to his execution site. Now, all the world is after him as he stumbles from one unfortunate incident to the next in order to prove himself innocent - by finding a mysterious one-eyed, one-armed, one-legged man...