Agent Phil Coulson of S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division) puts together a team of agents to investigate the new, the strange and the unknown around the globe, protecting the ordinary from the extraordinary.

One morning in an ordinary town, five people are shot dead in a seemingly random attack. All evidence points to a single suspect: an ex-military sniper who is quickly brought into custody. The interrogation yields one written note: 'Get Jack Reacher!'. Reacher, an enigmatic ex-Army investigator, believes the authorities have the right man but agrees to help the sniper's defense attorney. However, the more Reacher delves into the case, the less clear-cut it appears. So begins an extraordinary chase for the truth, pitting Jack Reacher against an unexpected enemy, with a skill for violence and a secret to keep.

Obstetrician/gynecologist Mindy Lahiri tries to balance her personal and professional life, surrounded by quirky co-workers in a small medical practice in New York City.