Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

In order to rescue the son of a diplomat who has been kidnapped by terrorists, a group of Las Vegas showgirls undergo commando training and organize a rescue operation.

Rico 'Honeyboy' Ramirez is a Puerto Rican from the South Bronx who finds fame and fortune as a middleweight boxer. But he soon learns that it's not all it's cracked up to be when he loses sight of his goals. He becomes romantically involved with his attractive publicist, and then he has to prove himself in the ring after learning that his biggest victory was rigged by his shady, mob-connected, promoters.