Goalkeeper Josef Bloch is sent off after committing a foul during an away game. This causes him to lose his bearings, and he wanders aimlessly through the city streets and spends the night with the box-office attendant of a movie theatre.

On New Year's Eve 1900, Paul Holzgruber started a new praxis as a radiologist. The young Maximiliane Frey is his assistant and they have worked side by side for years helping people. Holzgruber repeatedly points out the dangers of radiation to Maximiliane, but is silent about the ulcers on his hand and the severe pain they have caused. Maximiliane has gotten to know the widower Axel von Bonin and has fallen in love with him. But then she is diagnosed with incurable cancer. To spare Axel the inevitable grief over her impending death, she leaves him and dedicates what is left her life to medicine.