This musical is based on four short stories by Damon Runyon. In one tale, gambler Feet Samuels sells his body to science just as he realizes that Hortense loves him and that he would rather live than die. In another story, Harriet's parrot is killed, and she has problems dealing with her loss. Then, there is a gambler, "Regret", who has bloodhounds on his trail when he becomes a murder suspect. Finally, "The Brain" is bleeding profusely, and his friends search for a way to save his life through a blood transfusion.

A career criminal who has been deformed since birth is given a new face by a kindly doctor and paroled from prison. It appears that he has gone straight, but he is really planning his revenge on the man who killed his mentor and sent him to prison.

Robert McCall is a former agent of a secret government agency who is now running his own private crime fighting operation where he fashions himself as "The Equalizer." It is a service for victims of the system who have exhausted all possible means of seeking justice and have nowhere to go. McCall promises to even out the odds for them.

Sixteen-year-old Michael Dunn arrives at St. Basil's Catholic Boys School in Brooklyn circa 1965. There, he befriends all of the misfits in his class as they collide with the repressive faculty and discover the opposite sex as they come of age.

Harlem's legendary Cotton Club becomes a hotbed of passion and violence as the lives and loves of entertainers and gangsters collide.

Though visibly frail and weary, President Franklin D. Roosevelt runs for a precedent-setting fourth term. He also oversees plans for the D-Day Invasion and engages in tempestuous summit meetings with his wartime allies Stalin and Churchill.