A fugitive, an empty house, a rotting corpse. The journey begins. Cameron Matthews, a petty criminal and fugitive from the law, hides from police by taking shelter in an old dilapidated house in the middle of the city. There he discovers the rotting corpse of Bart Giordano, the owner of the house, whose death has gone unnoticed by friends and family for years. Though separated by death, the two men form an unlikely spiritual connection and help each other rebuild broken relationships in their personal lives.

A young boy fighting cancer writes letters to God, touching lives in his neighborhood and inspiring hope among everyone he comes in contact. An unsuspecting substitute postman, with a troubled life of his own, becomes entangled in the boy's journey and his family by reading the letters. They inspire him to seek a better life for himself and his own son he's lost through his alcohol addiction.

As America's stock of athletic young men is depleted during World War II, a professional all-female baseball league springs up in the Midwest, funded by publicity-hungry candy maker Walter Harvey. Competitive sisters Dottie Hinson and Kit Keller spar with each other, scout Ernie Capadino and grumpy has-been coach Jimmy Dugan on their way to fame.