A simple man, Dr. Walter Newman has high aspirations to cure all disease through genetic manipulation. His obsession with his mission draws him deeper into his own dark world, distracting him from his wife Olivia and from his responsibilities to his patients at the Edgewood Asylum. The doctor's loyal but diabolical nurse, Ms. Tinsley, decides to take matters into her own hands and in secret she conducts her own experiment. When Dr. Newman realizes what has been done, a deformed creature that defies nature is created. Part human, part nightmare. Dr. Newman knows what he must do, but is it already too late?

A young boy fighting cancer writes letters to God, touching lives in his neighborhood and inspiring hope among everyone he comes in contact. An unsuspecting substitute postman, with a troubled life of his own, becomes entangled in the boy's journey and his family by reading the letters. They inspire him to seek a better life for himself and his own son he's lost through his alcohol addiction.

It is freshman year at Coolidge College and Van Wilder is ready to party. To his dismay, all the girls have taken a vow of chastity and the dean rules the school. Van embarks on a crusade to land the campus hottie, Kaitlin, and liberate his school from sexual oppression and party dysfunction.

When a plane crash claims the lives of members of the Marshall University football team and some of its fans, the team's new coach and his surviving players try to keep the football program alive.

Shane Tanner, the son of a legendary cooler named Dalton, learns that his uncle Nate got beat up by a group of men because he doesn't want to sell his bar, The Black Pelican, to a bunch of drug dealers. To help out his uncle, Shane teams up with local school teacher Beau Hampton, who is a regular at the Black Pelican, and takes down the baddies.