Three years after the zombie virus has gutted the country, a team of everyday heroes must transport the only known survivor of the plague from New York to California, where the last functioning viral lab waits for his blood.

Kaveh and Raul are two b-movie co-writers who have suffered a bitter falling out. Kaveh's lost his girlfriend, and spends his days getting high in his apartment, while Raul is off studying at Columbia University. But when one of their films ("Islama-rama 2") is accepted by a film festival, the two ex-friends are forced to tentatively re-connect in order to pitch their script to the mysterious producer, Yukio Tai (James Hong). Along the way, they will have to brave brutish bodyguards, cutthroat colleagues, inept agents, romantic entanglements, prima donna actors, and the trials of their own bitter friendship.

An idyllic island town is under attack by that most invasive of pests: zombies! Port Gamble is being overrun with braineaters, and the people seem powerless to stave them off. But wait, a rag tag band of rebels is trying to turn the tide and push the invading hordes of undead back.