Reports of a weeping Madonna in Italy reach Las Vegas, where blackjack dealer Maggie has just learnt she has only weeks to live. With a massive leap of faith she convinces herself that seeing the Madonna with her own eyes could lead to her salvation, and travels to Europe to find it. Hitching through Italy, she meets pianist Mike, who is also en route to what he believes could be a life-changing event - a performance at the Barbarina concert in Naples.

Melanie Parker, an architect and mother of Sammy, and Jack Taylor, a newspaper columnist and father of Maggie, are both divorced. They meet one morning when overwhelmed Jack is left unexpectedly with Maggie and forgets that Melanie was to take her to school. As a result, both children miss their school field trip and are stuck with the parents. The two adults project their negative stereotypes of ex-spouses on each other, but end up needing to rely on each other to watch the children as each must save his job. Humor is added by Sammy's propensity for lodging objects in his nose and Maggie's tendency to wander.

Aging publisher Will Randall is at the end of his rope when a younger co-worker snatches his job out from under his nose. But after being bitten by a wolf, Will suddenly finds himself full of youthful vigor. As he struggles to regain his position, he becomes enthralled with Laura Alden, his former boss's daughter. And, as increasingly animal-like urges begin to overwhelm him, Randall worries that he may be turning into the creature that bit him.

When a corporate raider threatens a hostile takeover of a 'mom and pop' company, the patriarch of the company enlists the help of his wife's attractive daughter—who is a lawyer—to stop the takeover. However, the raider soon becomes infatuated with her, and enjoys the legal manoeuvring as he tries to win her heart.