Follows a criminal gang in Rome that has a near monopoly of the city's heroin trade. Besides their internal feuding, the gang has to deal with the Camorra and Sicilian Mafia that both supply its heroin, the police led by Commissioner Scialoja and the Italian secret services.

This series of sketches introduces doctor Apfelglück and four of his patients... and their rather peculiar and disturbing problems.

Amelia and Pippo are reunited after several decades to perform their old music-hall act, imitating Fred Astaire and Ginger Rogers, on a TV variety show.