Charming Sinners was a stilted adaptation of Somerset Maugham's play The Constant Wife. Robert Miles (Clive Brook) starts the ball rolling when he falls in love with Anne-Marie Whitley (Mary Nolan), the best friend of his own wife Kathryn (Ruth Chatterton). In retaliation, Kathryn begins a flirtation with her former boyfriend Karl Kraley (William Powell). After reels and reels of verbal fencing, the status quo is re-established, and Robert and Kathryn are reunited.

Jim Hutton and Mary Archer are two liberals who are content to remain faithful to each other in spirit only. They are married with all the ritual of a church wedding, the bride believing that each should be allowed perfect freedom in personal contacts. Complications arise when these ideals are put into practice.