William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

Jack Sadelstein, a successful advertising executive in Los Angeles with a beautiful wife and kids, dreads one event each year: the Thanksgiving visit of his twin sister Jill. Jill's neediness and passive-aggressiveness is maddening to Jack, turning his normally tranquil life upside down.

A depressed man moves back in with his parents following a recent heartbreak and finds himself with two women.

A cannibal stalks a dead-of-night police station

At home and school, she's Miley Stewart, a typical teenager, but when the lights go down and the curtain goes up, she emerges as the glamorous and talented Hannah Montana. Having the "Best of Both Worlds" is a complicated proposition, and keeping her identity under wraps leads Miley and her friends into some hilarious capers as she tries to balance her normal life with her rock star persona.

The Jack Bull tells the story of Myrl Redding, a Wyoming horse trader who clashes with Henry Ballard, a fellow rancher, after Ballard abuses two of Myrl's horses and their Crow Indian caretaker, Billy. When Judge Wilkins throws out Myrl's complaint, the war he wages to force Ballard to nurse the emaciated animals back to health escalates into a vigilante manhunt, murder and the possible defeat of Wyoming's bid for statehood.

A visiting city reporter's assignment suddenly revolves around the murder trial of a local millionaire, whom he befriends.