Following the events of Volume 1, the mutated glee club continue their violent rampage in Tromaville. Chrissy and Lauren, two innocent lesbian lovers, must fight not only the Cretins, mutants, and monsters but also the evil Tromorganic Foodstuffs Conglomerate. Can they, and Kevin the Wonder Duck, save Tromaville High School and the world?

Return to the Class of Nuke 'Em High follows a young couple that are up against the school glee club. Unfortunately, the glee club has mutated into a gang called The Cretins. When the other students begin to undergo mutations, our couple must solve the mystery and save Tromaville High School