Eddie Huntly, an east coast radio personality, moves to San Francisco to marry Thea, the sister of his best friend Neil, a successful entrepreneur. Shortly before Eddie's arrival, Neil is found murdered in what the police surmise was a simple mugging gone awry. As the sullen Eddie steps in as interim host of his old friend Dean's late-night talk-radio show, he obsessively makes regular visits to the forested spot where Neil's corpse was found. One such visit unleashes a chain of unpredictable events that sends Eddie snooping into the life of a sleepwalking drifter with a mysterious past.

The new medical director breaks the rules to heal the system at America's oldest public hospital. Max Goodwin sets out to tear up the bureaucracy and provide exceptional care, but the doctors and staff are not so sure he can succeed. They've heard this before. Not taking "no" for an answer, Dr. Goodwin's instinctive response to problems large and small is four simple words: "How can I help?" He has to disrupt the status quo and prove he'll stop at nothing to breathe new life into this underfunded and underappreciated hospital, returning it to the glory that put it on the map.

Liza Miller, a suddenly single stay-at-home mother, tries to get back into the working world, only to find it’s nearly impossible to start at the bottom at 40-year old. When a chance encounter convinces her she looks younger than she is, Liza tries to pass herself off as 26 and lands a job as an assistant at Empirical Press. Now she just has to make sure no one finds out the secret only she and her best friend Maggie share.

Since working as an adult film star and escort since his early twenties, Ryan Crosby, aka Rod Driver, has had a pretty easy life when you think about it. But what happens when you hit forty and the clients aren't calling as much as they used to and doing porn has, well... lost its appeal. Suddenly you begin to see things a bit clearer and you begin to ask yourself questions. What am I doing with my life? Is there something else I can do? What am I passionate about? You realize that you need to make a change. But how do you move forward from the life you no longer want? After an awkward meeting with a career counselor, who tries to extract information about his job history, Ryan heads home and the weight of his situation hits him hard.

Max Plugin is a jaded but flamboyant relic of the 1960s. In his teens, Max ran away to California, where he met Teschlock, a charismatic ascetic and guru renowned among a small group of young followers. At that time, when Teschlock asked Max to join him and his disciples on an ashram in India, Max declined and returned home. Now, forty years later, at age 57, Max takes a journey to India to find Teschlock's grave-site, and also himself. His adventures in India, and his Castaneda-esque experiences back home, form the heart of this very unusual road movie.

One night Cassie (Alanna Blair) indulges in some old habits and passes out in an alley. When she wakes, she finds in her pocket a strange Polaroid of herself with a mysterious man. This brush with the unknown draws her away from home and inexorably down a rabbit hole peopled with urchins, dealers, and a host of characters that the rest of the world has forgotten. For Cassie every choice leads her closer to the strangers in the picture - not only the man whose name is whispered among vagrants, but the woman she thought she knew as well.

Marin and Jim are two outsiders, drawn together by a shared history unknown even to them.

Jerry, an ambulance-chasing lawyer (and 8mm film hobbyist), lapses into a deep depression after he is scammed out of his retirement savings. His intense love of W.C. Fields, of whom he does impersonations, and his commitment to both his mixed-up half-sister Karen (who is going deaf and learning sign language) is the only thing keeping him from suicide.